This romance-drama set in 1980 is set during the Gwangju Uprising which is the backdrop for the blossoming love story between medical student Hwang Hee Tae (Lee Do Hyun) and a nurse named Kim Myung Hee (Go Min Shi).
Dr. Romantic 2 starts with Boo Yong Joo trying to revive Doldham Hospital with difficulties after his colleagues, Kang Dong Joo, Yoon Seo Jung, and Do In Beom – left the hospital. The hospital is short of doctors now, and he heads back to Geodae Hospital to look for doctors to replace them. Three doctors joined him. Are they able to revive the Doldham Hospital?
Yoon Soo-wan and Park Dong-joo were each other’s first loves. They were forced to separate due to some painful family circumstances. Soo-wan, who is blind, undergoes an eye transplant surgery that restores her sight. 12 years later, they meet again. However, she is engaged to a neurosurgeon. Will Dong-Joo and Soo-wan get back together?
Yoo Ryeong becomes a policewoman in order to find her twin sister. She solve cases with her strong sense of justice and does not follow rules. This gets her into trouble. She partners with Go Ji-seok, who always fight with her over the cases. However, he ends up cleaning up after the problems caused by Yoo Ryung and holds the key to solving the cases.