Dr. Romantic 2 starts with Boo Yong Joo trying to revive Doldham Hospital with difficulties after his colleagues, Kang Dong Joo, Yoon Seo Jung, and Do In Beom – left the hospital. The hospital is short of doctors now, and he heads back to Geodae Hospital to look for doctors to replace them. Three doctors joined him. Are they able to revive the Doldham Hospital?
Yook Dong-sik works in a brokerage company. One day, he witnesses a gruesome murder and comes across a diary that contains a detailed list of the murder logs. He flees and gets into a car accident. He lost his memory and thought that he is the psycho serial killer. His personality changes drastically.
A South Korean heiress of a conglomerate, Yoon Se-ri, while paragliding, met with a tornado accident that caused her to land in North Korea. There, she meets a North Korean army officer, Ri Jung-hyuk. He wants to arrest her initially but decides to let her go instead. Her escape fails. He hides and protects her instead.