Dr. Romantic 2 starts with Boo Yong Joo (Han Suk-kyu) trying to revive Doldham Hospital with difficulties after his colleagues, Kang Dong Joo, Yoon Seo Jung, and Do In Beom – left the hospital.
The hospital is short of doctors now, and he heads back to Geodae Hospital to look for doctors to replace them.
He found two doctors and gained a third one who applied to join Doldham hospital herself.
The first doctor is Seo Woo-jin (Ahn Hyo-seop), a second year general surgery fellow with a troubled past who is ostracized by his fellow doctors, and is out of job. He offers him a job.
The second doctor is Cha Eun-jae (Lee Sung-kyung), a second year cardiac surgery fellow. She is a top student at medical school, but always have difficulties performing a surgery without vomiting or falling asleep. She is suspended from Geodae Hospital and has to work for Master Teacher Kim before she can return to Geodae Hospital.
The third doctor is Yoon Ah-reum (So Joo-yeon), a fourth year emergency surgery specialist with a bright personality. She applied to the hospital after seeing Teacher Kim help patients in the emergency room of Geodae Hospital, despite everyone advising her not to.
Also, the president of Doldham Hospital is changed.
Will Master Teacher Kim be able to compete against the new president, Park Min-gook (Kim Joo-heon) and keep Doldham hospital in tact?
Are these new doctors able to help Master Teacher Kim revive the hospital back to their good old days?