Dr. Romantic 2 starts with Boo Yong Joo trying to revive Doldham Hospital with difficulties after his colleagues, Kang Dong Joo, Yoon Seo Jung, and Do In Beom – left the hospital. The hospital is short of doctors now, and he heads back to Geodae Hospital to look for doctors to replace them. Three doctors joined him. Are they able to revive the Doldham Hospital?
Yoon Soo-wan and Park Dong-joo were each other’s first loves. They were forced to separate due to some painful family circumstances. Soo-wan, who is blind, undergoes an eye transplant surgery that restores her sight. 12 years later, they meet again. However, she is engaged to a neurosurgeon. Will Dong-Joo and Soo-wan get back together?
A skilled doctor, Na Yi-je get involved in a medical accident which he did not cause. He is forced to quit the hospital where he works after being accused of medical malpractice. He then works in the prison with the goal of gathering sufficient connections to take his revenge against the people who forced him out of the hospital.
Cha Yo-han (Ji Sung) is a doctor of anesthesiology. He is arrogant, but he is a genius at his work. Kang Shi-young (Lee Se-young) is a resident of anesthesiology who works with Cha Yo-Han. She is smart, warm and listens carefully to her patients. People, with mysterious acute or chronic pain come to the hospital. There, Cha Yo-han and Kang Shi-young try to find the causes of their pain. Son Seok-ki (Lee Kyu-hyung), a prosecutor who is against the practice of euthanasia. He was the prosecutor during Yo-han’s trial and wanted to sentence him to ten years in prison. He holds a grudge against the Yo-han, the doctor who ended the life of his son’s murderer.